MYELINATION OF THE MOUSE CORPUS CALLOSUM

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Abstract
Sturrock R. R. (1980) Neuropathology and Applied Neurobiology 6, 415–420Myelination of the mouse corpus callosumMyelination has been studied in the corpus callosum of the mouse brain between birth and 240 days‐of‐age. Myelin sheaths were first seen at 11 days. The most rapid phase of myelination occurred between 14 and 45 days when 13–5% of axons were myelinated, but myelination continued at a reduced rate up to 240 days when 28% of axons were myelinated. The mean diameter of unmyelinated axons was more or less constant throughout the study with an overall mean diameter of 0–25 ± 0–01 μn. Similarly myelinated axon diameter showed little variation with age with a mean diameter of 0–46 ± 001 μn. This suggests that in the corpus callosum axons do not increase in size until they begin to myelinate.