The Measurement and Interpretation of Age-Specific Vaccine Efficacy
- 1 October 1992
- journal article
- research article
- Published by Oxford University Press (OUP) in International Journal of Epidemiology
- Vol. 21 (5) , 1014-1020
- https://doi.org/10.1093/ije/21.5.1014
Abstract
Farrrington C P (Communicable Disease Surveillance Centre, 61 Colindale Avenue, London NW9 5EQ, UK). The measurement and interpretation of age-specific vaccine efficacy. International Journal of Epidemiology 1992; 21: 1014–1020. The age-specific efficacy of a vaccine depends upon the mechanism of vaccine action and the force of infection in the unvaccinated subpopulation. Consequently, inferences concerning the persistence of vaccine-induced immunity cannot in general be made directly from age-specific vaccine efficacy estimates. The definition, estimation and interpretation of age-specific vaccine efficacy measures are discussed using simple models of vaccine action. The methods are applied to data on measles and pertussis vaccines.Keywords
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