Priming by DNA Immunization Augments Protective Efficacy ofMycobacterium bovisBacille Calmette-Guerin against Tuberculosis
- 1 June 2001
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 69 (6) , 4174-6
- https://doi.org/10.1128/iai.69.6.4174-4176.2001
Abstract
Sequential immunization with mycobacterial antigen Ag85B-expressing DNA and Mycobacterium bovis bacille Calmette-Guerin (BCG) was more effective than BCG immunization in protecting against Mycobacterium tuberculosis infection. Depletion of the CD8(+) T cells in the immunized mice impaired protection in their spleens, indicating that this improved efficacy was partially mediated by CD8(+) T cells.Keywords
This publication has 31 references indexed in Scilit:
- CpG Oligodeoxynucleotides and Interleukin-12 Improve the Efficacy ofMycobacterium bovisBCG Vaccination in Mice Challenged withM. tuberculosisInfection and Immunity, 2000
- CD4+and CD8+T Cells Mediate Adoptive Immunity to Aerosol Infection ofMycobacterium bovisBacillus Calmette‐GuérinThe Journal of Infectious Diseases, 2000
- Relative contributions of distinct MHC class I-dependent cell populations in protection to tuberculosis infection in miceProceedings of the National Academy of Sciences, 2000
- Characterization of human Mycobacterium bovis bacille Calmette-Guérin-reactive CD8+ T cells.1999
- Genetic vaccination strategies for enhanced cellular, humoral and mucosal immunityImmunological Reviews, 1999
- Induction of CD8+ T cells using heterologous prime‐boost immunisation strategiesImmunological Reviews, 1999
- Immunogenicity and efficacy of a tuberculosis DNA vaccine encoding the components of the secreted antigen 85 complexVaccine, 1997
- From Naive to Memory T CellsImmunological Reviews, 1996
- Immune response to Mycobacterium bovis bacille Calmette Guérin infection in major histocompatibility complex class I‐ and II‐deficient knock‐out mice: contribution of CD4 and CD8 T cells to acquired resistanceEuropean Journal of Immunology, 1995
- Efficacy of BCG Vaccine in the Prevention of TuberculosisJAMA, 1994