Myometrial activity in rats during the oestrous cycle and pseudopregnancy: interaction of oestradiol and progesterone.

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Abstract
Estradiol 17.beta. inhibits the rat myometrium, but the role of progesterone is uncertain. The interaction of 2 steroids in the control of uterine activity in pseudopregnancy and the estrous cycle was examined. Progesterone reversed the estradiol-induced inhibition of the myometrium in ovariectomized rats in vivo, but had little inhibitory effect of its own unless treatment was continued for several days. The frequency and amplitude of intrauterine pressure cycles was unaffected by pseudopregnancy, but during the estrous cycle frequency fell abruptly during late diestrus and did not recover until early estrus. Estradiol is apparently the major regulator of myometrial activity during the cycle; progesterone may interfere with its action, thereby paradoxically increasing uterine activity.

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