Neoantigenic Expressions Engendered by Plasmin Cleavage of Fibrinogen

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Abstract
Summary: Cleavage of fibrinogen to its pathophysiologic fragments by plasmin is associated with the appearance of unique neoantigens recognizable by Ouchterlony and radioimmunochemical techniques. Recognition of these cleavage-specific neoantigens by antisera to fibrinogen D-fragment introduces additional molecular markers for the study of fibrinogen conformation and also may permit direct assay of plasma for fibrinogen cleavage.