Brain and plasma exposure profiling in early drug discovery using cassette administration and fast liquid chromatography-tandem mass spectrometry
- 1 February 2004
- journal article
- Published by Elsevier in Journal of Pharmaceutical and Biomedical Analysis
- Vol. 34 (2) , 359-368
- https://doi.org/10.1016/s0731-7085(03)00523-5
Abstract
No abstract availableKeywords
This publication has 10 references indexed in Scilit:
- Simultaneous Screen for Microsomal Stability and Metabolite Profile by Direct Injection Turbulent-Laminar Flow LC−LC and Automated Tandem Mass SpectrometryAnalytical Chemistry, 2001
- Cassette‐accelerated rapid rat screen: a systematic procedure for the dosing and liquid chromatography/atmospheric pressure ionization tandem mass spectrometric analysis of new chemical entities as part of new drug discoveryRapid Communications in Mass Spectrometry, 2001
- Determination of brain and plasma drug concentrations by liquid chromatography/tandem mass spectrometryRapid Communications in Mass Spectrometry, 2000
- Bioanalytical High-Throughput Selected Reaction Monitoring-LC/MS Determination of Selected Estrogen Receptor Modulators in Human Plasma: 2000 Samples/DayAnalytical Chemistry, 2000
- Demonstration of the capabilities of a parallel high performance liquid chromatography tandem mass spectrometry system for use in the analysis of drug discovery plasma samplesRapid Communications in Mass Spectrometry, 1999
- Sample pooling to enhance throughput of brain penetration studyJournal of Pharmaceutical and Biomedical Analysis, 1999
- Cassette dosing: rapid in vivo assessment of pharmacokineticsPharmaceutical Science & Technology Today, 1998
- A direct technique for the simultaneous determination of 10 drug candidates in plasma by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry interfaced to a prospekt solid-phase extraction systemJournal of Pharmaceutical and Biomedical Analysis, 1997
- Simultaneous Pharmacokinetic Screening of a Mixture of Compounds in the Dog Using API LC/MS/MS Analysis for Increased ThroughputJournal of Medicinal Chemistry, 1997
- High-speed liquid chromatography/tandem mass spectrometry for the determination of drugs in biological samplesAnalytical Chemistry, 1986