Cav2.3 (α1E) Ca2+ channel participates in the control of sperm function
- 18 March 2002
- journal article
- Published by Wiley in FEBS Letters
- Vol. 516 (1-3) , 229-233
- https://doi.org/10.1016/s0014-5793(02)02529-2
Abstract
To know the function of the Ca2+ channel containing α12.3 (α1E) subunit (Cav2.3 channel) in spermatozoa, we analyzed Ca2+ transients and sperm motility using a mouse strain lacking Cav2.3 channel. The averaged rising rates of Ca2+ transients induced by α-D-mannose–bovine serum albumin in the head region of Cav2.3−/− sperm were significantly lower than those of Cav2.3+/+ sperm. A computer-assisted sperm motility assay revealed that straight-line velocity and linearity were greater in Cav2.3−/− sperm than those in Cav2.3+/+ sperm. These results suggest that the Cav2.3 channel plays some roles in Ca2+ transients and the control of flagellar movement.Keywords
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