The effect of external .GAMMA.-irradiation on 59Fe release in vitro from alveolar macrophages previously having ingested 59Fe-iron hydroxide colloid.
Open Access
- 1 January 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Radiation Research
- Vol. 31 (3) , 263-269
- https://doi.org/10.1269/jrr.31.263
Abstract
The effect of external γ-irradiation on the digestive function of rat alveolar macrophages (AM) was studied by using the in vitro assay system, where the 59Fe release from AM engulfing 59Fe-iron hydroxide colloid was measured as an indicator of their digestive capability. Graded doses of γ-irradiation up to 100 Gy had no effect on the extracellular release of 59Fe in AM cultured at 4 and 37°C for 8-72 hrs postirradiation. When 10 mM Ca-DTPA was added to the culture medium, the 59Fe release was slightly depressed by irradiation at a dose of 30 Gy. It is apparent from these results that γ-irradiation had no effect on the 59Fe transfer between cell and medium, and little effect on the catabolism of 59Fe-colloid in rat AM.This publication has 2 references indexed in Scilit:
- Patterns of lymphatic drainage to individual thoracic and cervical lymph nodes in the ratLaboratory Animals, 1987
- Radiosensitivity of Large Human MonocytesRadiation Research, 1978