Diffusion of oxygen at the endothelial surface of the rabbit cornea.

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Abstract
The O2 tension required at the endothelial surface of rabbit cornea (in vitro) to produce a net O2 flux into the cornea across this surface when the epithelial surface was exposed to air was determined. The experimental design was based on a mathematical model which showed that the direction of O2 flux measured in an agar layer adjacent to the endothelium was the same as the direction of O2 flux across the endothelial surface. From microelectrode measurements of O2 tension in the agar layer, an O2 tension greater than 102 mmHg at the endothelial surface was required to cause a net flux of O2 into the cornea. Comparing this result to the in vivo situation, it was concluded that all layers of the rabbit cornea receive O2 from the atmosphere under open eye conditions.