Plasmacytoid Dendritic Cells Are Highly Susceptible to Human Immunodeficiency Virus Type 1 Infection and Release Infectious Virus
Open Access
- 15 July 2001
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 75 (14) , 6710-6713
- https://doi.org/10.1128/jvi.75.14.6710-6713.2001
Abstract
Plasmacytoid dendritic cells (pcDC) and myeloid dendritic cells (myDC) are shown to express CD4 and low levels of CCR5 and CXCR4, but only myDC express DC SIGN, a C-type lectin that binds human immunodeficiency virus but does not mediate virus entry. Both DC types were more susceptible to infection with a macrophage than a lymphotropic strain of human immunodeficiency virus type 1, but pcDC were more readily infected than myDC.Keywords
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