Effect of varying the length of exposure to polybrominated biphenyls on the development of gamma-glutamyl transpeptidase enzymealtered foci

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Abstract
Female Sprague-Dawley rats were fed polybrominated biphenyls (PBBs) for 15 or 140 days after a 70% partial hepatectomy and diethylnitrosamiw administration (10 mg/kg body weight) to determine the effect of varying the length of exposure to PBBs on the enhancement of gamma utamyl traospeptidase enzyme-alted foci. fireMaster BP-6 R , a cornmedal mbrture of PBBs, was fed to rats at a dietary concentration of 100 mg/kg for 15 days or 10 mg/kg for 140 days during the promotion phase of a two-stage hepatocarcinogenesis assay. Results indicate that short term exposure to PBBs is as effective as long term exposure in enhandog the development of enzyme-altered foci.