5-Substituted 2-furancarbaldehydes and water-soluble furan derivatives

Abstract
5-Halo-2-furaldehydes Ia, Ib react with trimethylamine in aprotic solvents to furnish 5-trimethyl-ammonium salts of 2-furaldehyde IIa, IIb. The reactivity of this salt was utilized for a simple preparation of 5-substituted 2-furaldehydes IV in water at room temperature. The possibility to synthesize azomethines V and ethylenes VI, having the trimethylammonium group in position 5 of the furan ring maintained, is discussed.

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