ALCOHOL-MEMBRANE INTERACTION - CALCIUM-UPTAKE IN MITOCHONDRIA

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  • 1 January 1977
    • journal article
    • letter
    • Vol. 18  (3) , 569-572
Abstract
A biphasic effect of ethanol was observed on Ca2+-uptake activity, Ca2+-uncoupled respiratory control ratio and State 3 O2 uptake [in rat liver mitochondria]. At low concentrations (0.1-0.5%) ethanol enhanced these activities, probably as the result of an increase in membrane fluidity. At higher levels (0.7-4.0%) ethanol had an inhibitory influence on mitochondrial activities as the membrane macromolecules were probably disturbed due to the hydrophobic alcohol-membrane interaction.

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