RECOVERY OF HEMATOLOGIC COMPETENCE WITHOUT ENGRAFTMENT FOLLOWING ATTEMPTED BONE-MARROW TRANSPLANTATION FOR APLASTIC-ANEMIA - REPORT OF A CASE WITH DIFFUSION CHAMBER STUDIES
- 1 January 1977
- journal article
- research article
- Vol. 5 (1) , 51-58
Abstract
An 18 yr old male with severe aplastic anemia associated with hepatitis was prepared for bone marrow transplantation with cyclophosphamide (50 mg/kg per day) for 4 consecutive days. He then received 3.47 .times. 108 nucleated bone marrow cells/kg of body wt from his HL-A identical sister by i.v. infusion. Although subsequent karyotyping showed that engraftment was not achieved, prompt hematologic recovery ensued by the 3rd wk post-transplant. Diffusion chamber culture of the patient''s bone marrow stroma, obtained prior to cyclophosphamide therapy, was carried out. A prompt increase in the number of cells in the chambers was observed. A differential cell count of the contents was similar to that seen when normal bone marrow is cultured in a similar manner.This publication has 3 references indexed in Scilit:
- Regeneration of Locally Irradiated Bone Marrow. II. Induction of Regeneration in Permanently Aplastic Medullary CavitiesBlood, 1968
- REGENERATION OF LOCALLY IRRADIATED BONE MARROW .I. DOSE DEPENDENT LONG-TERM CHANGES IN RAT WITH PARTICULAR EMPHASIS UPON VASCULAR AND STROMAL REACTION1966
- APLASTIC ANEMIA TREATED WITH DAILY TRANSFUSIONS AND INTRAVENOUS MARROW; CASE REPORTAnnals of Internal Medicine, 1939