THE EFFECT OF TESTOSTERONE TREATMENT ON THE UPTAKE OF [3H]OESTRADIOL-17β BY DIMETHYLBENZANTHRACENE-INDUCED RAT MAMMARY TUMOURS

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Abstract
The use of androgens to cause the regression of mammary tumours in both rats and women is well established, but the mechanism by which they act is still obscure. Since it has been shown that some human breast tumours and oestrogen-responsive dimethylbenzanthracene (DMBA)-induced rat mammary tumours retain injected oestrogen, a possible mechanism for testosterone action might be the prevention of the concentration of oestrogen by the tumour tissue. Deshpande, Jensen, Bulbrook, Berne & Ellis (1967) had reported that pretreatment with dromostanolone propionate decreased the amount of injected [3H]oestradiol-17β present in human breast tumours compared with that in control patients, but this effect of androgen treatment has not been confirmed by Braunsberg, Carter, Irvine & James (1969). The effect of various testosterone treatments on the uptake of [6,7-3H]oestradiol by DMBA-induced mammary tumours of the rat is reported here. Mammary tumours were induced in female Sprague—Dawley rats by the

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