NALOXONE WITHOUT TRANSFUSION PROLONGS SURVIVAL AND ENHANCES CARDIOVASCULAR FUNCTION IN HYPOVOLEMIC SHOCK
- 1 January 1982
- journal article
- research article
- Vol. 220 (3) , 621-624
Abstract
The hypothesis that opiate receptors are involved in the cardiovascular pathophysiology of hypovolemic shock was tested by using the opiate receptor antagonist naloxone. Naloxone increased mean arterial pressure, cardiac output, stroke volume and left ventricular dP/dtmax [maximum pressure change with time] in a canine hemorrhagic shock model. Naloxone treatment also prolonged survival time. All these responses were dose-dependent and were independent of blood reinfusion. Evidently, endorphins activated by stress act on opiate receptors to bring about some of the cardiovascular abnormalities in hypovolemic shock.This publication has 5 references indexed in Scilit:
- NALOXONE REVERSAL OF HYPOVOLEMIC SHOCK IN DOGS1980
- BLOCKADE OF OPIATE RECEPTORS WITH NALOXONE IMPROVES SURVIVAL AND CARDIAC-PERFORMANCE IN CANINE ENDOTOXIC-SHOCK1980
- Opiate Antagonists: A Role in the Treatment of Hypovolemic ShockScience, 1979
- CONCISE REVIEW - SUBCELLULAR FUNCTION IN THE ACUTELY FAILING MYOCARDIUM1979
- β-Endorphin and Adrenocorticotropin Are Selected Concomitantly by the Pituitary GlandScience, 1977