GLUCOCORTICOID AND MINERALOCORTICOID ACTIONS ON GASTRIC-SECRETION IN MAN

  • 1 January 1977
    • journal article
    • research article
    • Vol. 24  (1) , 34-37
Abstract
The effects of a 6 day course of treatment with a glucocorticoid (prednisolone, 1 g/day i.v.), a mineralocorticoid (9-.alpha.-fluorohydrocortisone, 0.3 mg/day orally), or both the drugs on gastric secretion of acid, protein, pepsin and N-acetylneuraminic acid (NANA) containing glycoproteins were investigated in 22 volunteers. None of the treatments produced any statistically significant changes in gastric secretion of aggressive factors, acid and pepsin. The output of protective NANA bound to glycoproteins decreased following prednisolone. The prednisolone effect was not prevented by 9 .alpha.-fluorohydrocortisone given concomitantly. Gastroduodenoscopy did not reveal any lesions attributable to drug administration. [In man, development or reactivation of peptic ulceration is a serious side-effect of prolonged corticosteroid or ACTH treatment.].

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