The Effect of Protoveratrine a on Potassium and Calcium Ion Movements in Muscle and Nerve

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Abstract
The effects of protoveratrine A on the efflux of potassium ions (K+) from frog and rat skeletal muscle and the isolated electrically driven rat heart have been studied. No effect was seen upon the rate of efflux from skeletal muscle but that from the heart was increased. Protoveratrine A increases K+ uptake from frog skeletal muscle and causes this tissue to release more calcium (Ca++). There was no increase in Ca++ release from lobster nerve treated with protoveratrine A. The theoretical implications of these findings are discussed.

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