Blocking IL-1 in systemic inflammation
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Open Access
- 2 May 2005
- journal article
- review article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 201 (9) , 1355-1359
- https://doi.org/10.1084/jem.20050640
Abstract
A growing number of systemic inflammatory diseases characterized in part by recurrent fevers, leukocytosis, anemia, and elevated acute phase proteins are linked to interleukin (IL)-1 activity since rapid and sustained resolution is observed upon specific blockade of IL-1 receptors. Rapid resolution of systemic and local inflammation is now also reported in systemic onset juvenile idiopathic arthritis (SoJIA). Loss of control of the secretion of IL-1β might be a common mechanism explaining the aberrant activity of IL-1 in these diseases.Keywords
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