Cerebral Complications of Serum Sickness

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Abstract
The manifestations in the nervous system of serum sickness are reviewed, with preliminary brief discussion of the peripheral type called serum neuritis. The uncommon cerebral effects of serum sickness are reviewed in detail and 3 new cases are reported. Two of these cases developed hemiplegia with serum sickness following injns. of anti-tetanic serum. One of these recovered, the other was permanently paralyzed and aphasic. The 3d case had transient but rather severe diffuse cerebral effects. A review of the literature reveals only 9 previous cases with focal cerebral damage from serum sickness. The pathology of serum sickness is discussed with some comment on the similarity of the neurological complications to those of acute virus exanthemata, infectious mononucleosis and collagen diseases.
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