IgM M-protein in a patient with sensory-dominant neuropathy binds preferentially to polysialogangliosides

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Abstract
A 77‐year‐old man presented sensory‐dominant neuropathy associated with IgM M‐protein reacting with various gangliosides. The M‐protein bound to gangliosides with polysialosyl residue, such as GD1b, GD3, GT1b, GT3, GQ1b, and GQ1c. In addition, GD1a, GM3 and LM1, having a terminal monosialosyl epitope, were also recognized. Previously, Ilyas et al. described a similar case in which sensory symptoms were associated with IgM M‐protein reacting with gangliosides containing a disialosyl group, such as GD3, GD1b, and GT1b, but not GM3 and GD1a. It is suggested that the reactivity of IgM M‐protein with polysialogangliosides may be associated with the pathogenesis of sensory‐dominant neuropathy.