A model for tumor cell killing by topoisomerase poisons.
- 1 January 1990
- journal article
- review article
- Vol. 2 (1) , 23-7
Abstract
Our model proposes that topoisomerase-targeting antitumor drugs form reversible drug-enzyme-DNA complexes that collide with the DNA and RNA synthesis machineries. On collision, the complexes lose their reversibility, and generate lethal double-strand DNA breaks. Further investigations of topoisomerase action will allow this model to be refined, and may ultimately lead to the development of more effective anticancer drugs.This publication has 0 references indexed in Scilit: