Immunohistology in Renal DiseaseDIAGNOSTIC, PROGNOSTIC, THERAPEUTIC, AND ETIOLOGIC VALUE AND LIMITATIONS

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Abstract
Immunohistological localization of IgG and β1 was performed on 438 renal biopsy specimens from 340 patients. We found this technique to be of special value in early cases of S.L.E. where it may suggest a rapid development of some kidney disease when urinary abnormalities are still minimal; and in renal transplants where it may indicate chronic rejection rather than recurrent glomerulonephritis when bight microscopy shows changes compatible with either. It is also useful in the diagnosis of membranous nephropathy; the nephrotic syndrome where morphological classification of minimal change and focal or segmental lesions are in doubt; in patients with asymptomatic hematuria, proteinuria or both; diabetes, rheumatoid arthritis, malignant hypertension; and in the prognosis of acute post-streptococcal nephritis. We have also reported results of attempts at antigen localization, and suggested that this may add a new tool to the therapy of glomerular disease.

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