Effects of cis-Dichlorodiammine Platinum (II) in the Regression of Sarcoma 180: A Fine Structural Study.2

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Abstract
Sarcoma 180, a transplantable tumor in Swiss white mice, regressed completely after a single intraperitoneal injection of cis-dichlorodiammine platinum (II) (cis-Pt-ll), with no apparent irreversible damage to the host. Fine structural studies before and after cis-PHI treatment showed certain morphologic changes indicative of possible mechanisms involved in tumor regression. The mitotic activity of the tumor cells was inhibited soon after treatment with platinum. Plasma cells and lymphocytes appeared within the tumor mass after 4-6 days of treatment. Spleens of both treated and control animals had a greater number of plasma cells after 5 days of treatment. An increase in the lymphocytes and plasma cells indicated an enhancement of the immune system at the cellular level. Also, the double diffusion method on agar plates indicated an enhanced antibody production against Sarcoma 180, as opposed to the controls. Serum protein analysis with gel electrophoresis showed a marked enhancement of a1 and a2 bands from day 4 to day 10 of platinum treatment. After 4 days of such treatment, large multinucleate cells with well-developed Golgi were observed within the mass of the tumor tissue.

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