Abstract
A patient with persistent leukopenia and recurring pulmonary infections for a decade was found to have systemic lupus erythematosus (SLE) in 1960. Adrenocorticosteroid therapy was given and the patient improved, only to develop acute myeloblastic leukemia 5 years later and die shortly thereafter. This is believed to be the 1st documented report of an SLE patient developing acute myeloblastic leukemia. A brief survey of conceivable pathogenetic mechanisms relating autoimmune disease to leukemia and lymphoma is presented.

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