Skin‐tumor initiation activity of coal liquids with different boiling‐point ranges
- 1 October 1983
- journal article
- Published by Wiley in Journal of Applied Toxicology
- Vol. 3 (5) , 254-258
- https://doi.org/10.1002/jat.2550030507
Abstract
High‐boiling coal liquids from the solvent‐refined coal‐I and ‐II (SRC‐I, ‐II) processes, respectively, were fractionally distilled. In the case of SRC‐I process solvent (PS), 50°F distillation cuts were obtained between 550 and 850°F, while for the SRC‐II material, the 50°F cuts were only obtained between 700 and 850°F. These cuts, as well as the parent material, were tested for their ability to initiate skin tumors by applying a single dose (25 mg) to the shaved backs of Charles River female CD‐1 mice. After 2 weeks, the mice received twice weekly applications of 5 μg of the promoter, phorbol myristate acetate. Only a few tumors were found for SRC‐I fractions boiling below 700°F; tumor‐initiating activity increased as the boiling point increased. A similar increase in response with increasing boiling point was seen for the SRC‐II cuts. The initiating activities for the parent materials were similar to those observed for their respective 800 to 850°F cuts.Keywords
This publication has 8 references indexed in Scilit:
- Chemical characterization and genotoxic potential related to boiling point for fractionally distilled SRC-I coal liquidsPublished by Office of Scientific and Technical Information (OSTI) ,1982
- The effects of nitrous acid on the mutagenicity of two coal liquids and their genetically active chemical fractionsMutation Research/Genetic Toxicology, 1981
- Chemical class separation and characterization of organic compounds in synthetic fuelsAnalytical Chemistry, 1981
- Fractional distillation as a strategy for reducing the genotoxic potential of SRC-II coal liquids: a status reportPublished by Office of Scientific and Technical Information (OSTI) ,1981
- Polycyclic aromatic primary amines as determinant chemical mutagens in petroleum substitutesEnvironmental Research, 1980
- Epidemiologic Study of Occupational Lung CancerArchives of environmental health, 1967
- The Hazards to Health in the Hydrogenation of CoalArchives of environmental health, 1960
- The Identification of a Carcinogenic Compound in Coal-tarBMJ, 1955