Mouse Thymocyte Membrane Uptake of Polyadenylic-Polyuridylic Acid Complexes

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Abstract
Indirect immunofluorescence revealed that 80 .+-. 4% of isolated mouse thymocytes had membrane uptake of Poly (A:U) [a known immunologic stimulator of thymocytes]. Mice previously injected with hydrocortisone demonstrated a reduction to 20-30% in numbers of fluorescent thymocytes. Preincubation of thymocytes with DEAE-dextran did not increase the percentage of fluorescent cells. Medullary thymocytes apparently bind Poly (A:U) to a lesser degree than cortical thymocytes. Several mechanisms of thymocyte uptake of Poly (A:U) are suggested, including adsorption to the membrane and/or rapid penetration through the membrane.

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