Experimental and human studies on antimony metabolism: their relevance for the biological monitoring of workers exposed to inorganic antimony.
Open Access
- 1 February 1991
- journal article
- case report
- Published by BMJ in Occupational and Environmental Medicine
- Vol. 48 (2) , 93-97
- https://doi.org/10.1136/oem.48.2.93
Abstract
Unlike inorganic arsenic, inorganic trivalent antimony (Sb) is not methylated in vivo. It is excreted in the bile after conjugation with glutathione and also in urine. A significant proportion of that excreted in bile undergoes an enterohepatic circulation. In workers exposed to pentavalent Sb, the urinary Sb excretion is related to the intensity of exposure. It has been estimated that after eight hours exposure to 500 micrograms Sb/m3, the increase of urinary Sb concentration at the end of the shift amounts on average to 35 micrograms/g creatinine.Keywords
This publication has 7 references indexed in Scilit:
- Biological Monitoring of AntimonyPublished by Springer Nature ,1988
- Biological assessment of exposure to antimony and lead in the glass-producing industryInternationales Archiv für Arbeitsmedizin, 1987
- Study of inorganic arsenic methylation by rat liver in vitro: relevance for the interpretation of observations in manArchives of Toxicology, 1985
- Determination of antimony(III), antimony(V), and methylantimony species in natural waters by atomic absorption spectrometry with hydride generationAnalytical Chemistry, 1981
- Comparison of several methods for the determination of arsenic compounds in water and in urineInternationales Archiv für Arbeitsmedizin, 1980
- Separation of arsenic metabolites in dog plasma and urine following intravenous injection of 74AsAnalytical Biochemistry, 1978
- Tissue sulfhydryl groupsArchives of Biochemistry and Biophysics, 1959