THE PHARMACOKINETICS OF [14C]‐EDROPHONIUM IN NORMAL WISTAR RATS AND HOMOZYGOUS GUNN RATS WITH LIGATED RENAL PEDICLES
Open Access
- 1 May 1974
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 51 (1) , 61-65
- https://doi.org/10.1111/j.1476-5381.1974.tb09632.x
Abstract
1 The distribution kinetics of [14C]-edrophonium were studied in both normal Wistar and homozygous Gunn rats with ligated renal pedicles. 2 After intravenous injection the plasma concentration-time curve of [14C]-edrophonium was adequately fitted by a triexponential function in both species of rat and interpreted in terms of a three compartment model. 3 The influence of the route of administration (i.e., systemic venous versus hepatic portal) of [14C]-edrophonium on its concentration in plasma was studied in normal Wistar rats with ligated renal pedicles. There was a marked difference in the area under the plasma concentration-time curve depending on the route of administration. 4 The parameters of the model were determined and compared. 5 The value of the metabolism rate constant was approximately the same in both species of rat. This suggests that the rate of conjugation of [14C]-edrophonium is unaltered in the homozygous Gunn rat despite the genetic lesion in UDP-glucuronyltransferase.Keywords
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