Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cells
- 1 June 2007
- journal article
- review article
- Published by Springer Nature in Nature Reviews Genetics
- Vol. 8 (6) , 462-472
- https://doi.org/10.1038/nrg2103
Abstract
Recent genetic studies in flies have added further support to an increasing body of evidence that suggests that stem cells might be the cell-of-origin of certain tumours. Malfunction of the mechanisms that control the division of stem cells and the developmental fate of the two resulting daughters could be one of the initial events that steers cells into malignant transformation. These studies suggest a role for controlled spindle orientation in suppressing stem-cell overgrowth. In parallel, the machinery that drives asymmetry in stem cells has been further characterized, identifying new components and uncovering the unique, highly sophisticated behaviour of centrosomes in these cells.Keywords
This publication has 113 references indexed in Scilit:
- Glioma stem cells promote radioresistance by preferential activation of the DNA damage responseNature, 2006
- Drosophila brain tumor metastases express both neuronal and glial cell type markersDevelopmental Biology, 2006
- Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9Nature, 2006
- Drosophila Neuroblast Asymmetric Cell Division: Recent Advances and Implications for Stem Cell BiologyNeuron, 2006
- Evidence that stem cells reside in the adult Drosophila midgut epitheliumNature, 2005
- The adult Drosophila posterior midgut is maintained by pluripotent stem cellsNature, 2005
- Self-renewal and solid tumor stem cellsOncogene, 2004
- Fusion of retinoic acid receptor α to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukaemiaNature Genetics, 1997
- Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cellNature Medicine, 1997
- Phenotypic diversity in experimental hepatomas: the concept of partially blocked ontogeny. The 10th Walter Hubert LectureBritish Journal of Cancer, 1978