A stereoselective total synthesis of 17-O-acetyl-14α-hydroxy-3-O-methyl-11-oxo-estradiol-17β
- 1 January 1980
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 12,p. 2793-2796
- https://doi.org/10.1039/p19800002793
Abstract
A stereoselective total synthesis of the title compound (13) was achieved with thermolysis of 3-hydroxy-2-[2-benzyloxy-2-(4-methoxy-1,2-dihydrobenzocyclobutenyl)ethyl]-2-methyl-3-vinylcyclopentan-1-one (1) as the key step. Compound (13) was converted into 14,15-didehydro-3-O-methylestradiol-17β which was identified by comparison with an authentic sample.Keywords
This publication has 2 references indexed in Scilit:
- Total synthesis of 14α-hydroxyestrone 3-methyl etherJournal of the Chemical Society, Perkin Transactions 1, 1979
- Asymmetric total synthesis of estradiol by an intramolecular cycloaddition of benzocyclobutene derivativeJournal of the American Chemical Society, 1978