Fibroadenoma of the breast: Diagnostic pitfalls of fine‐needle aspiration
- 1 November 1992
- journal article
- focus on-technology
- Published by Wiley in Diagnostic Cytopathology
- Vol. 8 (6) , 643-647
- https://doi.org/10.1002/dc.2840080623
Abstract
On fine-needle aspiration (FNA), fibroadenomas have a characteristic cytological appearance, although occasional cases are misinterpreted as carcinomas and vice versa. In a review of 521 breast aspirates correlated with the subsequent histology, six of 87 fibroadenomas (7%) were malignant or suspicious of malignancy on FNA (false positives). Following cytological review, four were still suspicious of malignancy because of cellular dyscohesion and prominent nucleoli, while two were fibroadenomas. On FNA, four of 145 carcinomas (3%) were diagnosed as fibroadenomas (false negatives). On review, three were malignant or suspicious of malignancy, while one was consistent with a fibroadenoma. Three false negative diagnoses were due to underappreciation of single malignant cells present between epithelial groupings typical of a fibroadenoma, while one was due to undersampling of the carcinoma. Cytologically, some fibroadenomas are sufficiently atypical that histological confirmation is necessary to exclude a malignancy. Misinterpreting carcinomas as fibroadenomas could be avoided by careful study of the morphology of isolated cells.Keywords
This publication has 4 references indexed in Scilit:
- Fine‐needle aspiration of fibroadenomas of the breast with atypia: A spectrum including cases that cytologically mimic carcinomaDiagnostic Cytopathology, 1990
- Fibroadenoma of the breast: A follow-up of conservative managementBritish Journal of Surgery, 1989
- Cytologic Criteria for Fibroadenoma: A Step-Wise Logistic Regression AnalysisAmerican Journal of Clinical Pathology, 1988
- Fine-needle aspiration of breast cancer: Relationship of clinical factors to cytology results in 689 primary malignanciesCancer, 1986