THE EFFECT OF DESOXYCORTICOSTERONE ON THE ENDOMETRIUM OF MONKEYS

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Abstract
The fact that the properties of progesterone and desoxycorticosterone overlap is indicated on the one hand by experiments which show that progesterone produces some of the specific effects of desoxycorticosterone and on the other by experiments which demonstrate that desoxycorticosterone has a progestational effect on the endometrium. In the first case it has been shown: (a) that progesterone prolongs the life of adrenalectomized animals [Gaunt & Hays, 1938, working on ferrets; Gaunt, Nelson & Loomis, 1938; Bourne, 1939; Schwabe & Emery, 1939; Tobin, 1939; Greene, Wells, & Ivy, 1939, all working on rats; Corey, 1939, working on cats], an observation which explains the longer survival time of animals adrenalectomized in pregnancy or pseudo-pregnancy [e.g. Rogoff & Stewart, 1927; Swingle, Parkins, Taylor, Hays & Morrell, 1937; Gaunt & Hays, 1938] and of adrenalectomized animals treated with luteinizing hormone [D'Amour & D'Amour, 1939]; (b) that progesterone causes water and salt retention [Thorn,

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