Cellular Changes in the Bone Marrow Following Chronic Treatment of Rats with Cortisol

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Abstract
Chronic treatment of rats with large doses of cortisol resulted in a significant reduction of the lymphocyte content of the bone marrow. Cortisol also produced an increase in the absolute numbers of neutrophils in the marrow but did not alter significantly either the nucleated eryth-roid cells or the total marrow cellularity. The cellular changes in the marrow occurred concomitant with a reduction in thymic tissue mass and a loss in total body weight.

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