Inhibition of N-nitrosodimethylamine metabolism by ethanol and other inhibitors in the isolated perfused rat liver
- 1 January 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 5 (1) , 113-116
- https://doi.org/10.1093/carcin/5.1.113
Abstract
The effects of several potential inhibitors of N-nitrosodimethylamine (NDMA) [a carcinogen] metabolism were studied in isolated perfused rat livers. Low concentrations of ethanol (< 0.5 mM) strongly inhibited hepatic metabolism of NDMA. This effect does not require the metabolism of ethanol. The metabolism and toxicity of NDMA may therefore be influenced by the intake of alcohol as well as by ethanol produced endogenously by the intestinal flora. Other compounds inhibiting NDMA metabolism include n-propanol, tert-butanol, 4-methylpyrazole, aminotriazole and acetaldehyde.This publication has 10 references indexed in Scilit:
- PHARMACOKINETIC MODEL FOR N-NITROSODIMETHYLAMINE BASED ON MICHAELIS-MENTEN CONSTANTS DETERMINED WITH THE ISOLATED PERFUSED-RAT-LIVER1983
- The induction and competitive inhibition of a high affinity microsomal nitrosodimethylamine demethylase by ethanolCarcinogenesis: Integrative Cancer Research, 1982
- Effect of ethanol on dimethylnitrosamine activation and DNA synthesis in rat liverCarcinogenesis: Integrative Cancer Research, 1982
- ENHANCEMENT OF DIMETHYLNITROSAMINE METABOLISM AND ACTIVATION TO A MUTAGEN FOLLOWING CHRONIC ETHANOL-CONSUMPTION1981
- Bioactivation of dimethylnitrosamine in intrasanguinous host-mediated assay and its association with in vitro mutagenesis assaysMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1980
- Effect of ethanol on microsomal metabolism of dimethylnitrosamineZeitschrift für Krebsforschung und Klinische Onkologie, 1980
- INTERACTIONS BETWEEN ETHANOL-METABOLISM AND MIXED-FUNCTION OXIDATION IN PERFUSED-RAT-LIVER - INHIBITION OF PARA-NITROANISOLE O-DEMETHYLATION1980
- The distribution of [14C]dimethylnitrosamine in mice. Autoradiographic studies in mice with inhibited and noninhibited dimethylnitrosamine metabolism and a comparison with the distribution of [14C]formaldehydeToxicology and Applied Pharmacology, 1978
- STUDIES ON THE PATHOGENESIS OF THE ETHANOL-INDUCED FATTY LIVER. I. SYNTHESIS AND OXIDATION OF FATTY ACIDS BY THE LIVER*Journal of Clinical Investigation, 1961
- Properties of catalase. Catalysis of coupled oxidation of alcoholsBiochemical Journal, 1945