Current issues of 13 "mass" magazines, each with a minimum circulation of one million copies per average issue, contain articles on drugs, such as: systemic antiinfectives (including antibiotics, sulfonamides,tuberculostatics), antihistamines, tranquilizers, and anorexigenics. From such information, millions of persons have gained impressions which they intend to discuss with their physicians. During 1959, as compared with 1949, purchases of drugs have shown an increase of almost 150%. out of 10 dentists are now prescribing drugs. More than 630 million prescriptions were filled by the nation's pharmacies during 1959, and additional, substantial increases have been predicted for 1960 (in figures now being compiled) and for 1961.1 short, more people are going to be exposed to reactions from drugs, because more peoplee using more drugs. Only one type of reaction from drugs, the fixed eruption, is the subject of this report. Definition of the "Fixed Eruption" Soon after 1885 when antipyrine into use, observers began to