IMPORTANCE OF PRESSURE FACTORS IN THE GENESIS OF PULMONARY EDEMA FOLLOWING VAGOTOMY

Abstract
Guinea pigs anesthetized with pentobarbital sodium and maintained on artificial positive pressure respiration were divided into 2 groups, one group being subjected to 6 mm. Hg respiration pressure and the other group to 20 mm. Hg pressure. In addition, each group was divided into 2 subgroups, one subgroup having bilateral cervical vagotomy and the other subgroup having intact vagi. At 6 mm. Hg pressure neither intact nor vagotomized guinea pigs developed pulmonary edema in 5-25 hrs. of artificial respiration but with 20 mm. Hg pressure both subgroups had massive pulmonary edema in 4 hrs. Under artificial respiration, pressure is the predominant factor determining pulmonary edema and vagotomy is without a significant effect.
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