Linking the Cellular Functions ofBRCAGenes to Cancer Pathogenesis and Treatment
Top Cited Papers
- 1 February 2009
- journal article
- review article
- Published by Annual Reviews in Annual Review Of Pathology-Mechanisms Of Disease
- Vol. 4 (1) , 461-487
- https://doi.org/10.1146/annurev.pathol.3.121806.151422
Abstract
Single-gene disorders that predispose to cancer afford a unique window into the mechanisms of carcinogenesis. I argue that the instability in chromosome structure and number provoked by inactivatio...Keywords
This publication has 143 references indexed in Scilit:
- Common Breast Cancer-Predisposition Alleles Are Associated with Breast Cancer Risk in BRCA1 and BRCA2 Mutation CarriersPublished by Elsevier ,2008
- Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancersNature, 2008
- Genome-wide association study identifies novel breast cancer susceptibility lociNature, 2007
- Identification of the FANCI Protein, a Monoubiquitinated FANCD2 Paralog Required for DNA RepairCell, 2007
- PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility geneNature Genetics, 2006
- The DNA helicase BRIP1 is defective in Fanconi anemia complementation group JNature Genetics, 2005
- A novel ubiquitin ligase is deficient in Fanconi anemiaNature Genetics, 2003
- Insights into DNA recombination from the structure of a RAD51–BRCA2 complexNature, 2002
- The Hallmarks of CancerCell, 2000
- Identification of a RING protein that can interact in vivo with the BRCA1 gene productNature Genetics, 1996