Expedient synthesis of natural (S)-sinefungin and of its C-6′ epimer
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 5,p. 981-985
- https://doi.org/10.1039/p19910000981
Abstract
Sinefungin 1a and 6-epi-sinefungin 1b have been prepared from adenosine and L-aspartic acid. The key step in the synthesis was the coupling of the radical derived from 14 with the unsaturated amide 13. The latter was obtained by a radical reaction from L-aspartic acid and olefin 11. Thus the carbon skeleton is constructed in two radical coupling reactions.Keywords
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