BICYCLE ENDURANCE PERFORMANCE OF PATIENTS WITH INTERSTITIAL LUNG-DISEASE BREATHING AIR AND OXYGEN

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Abstract
The effect of supplemental O2 breathing on bicycle exercise performance was studied in 16 patients in the assessment of their extent of impairment with interstitial lung disease (ILD). The mean maximal working capacity (W-Max) .+-. 1 SD with incremental exercise breathing air was 107 .+-. 43 W (60% predicted). There was no significant increase in W-Max with O2 breathing (P < 0.10, n .**GRAPHIC**. 12). On a separate day, each patient performed 2 endurance studies at a constant submaximal work load (80% W-Max) inspiring air and 60% O2. The mean fall in arterial HbO2 saturation (SaO2%) during exercise in air was 8% (range, 1-23%). There was a significant improvement in exercise time (P < 0.001) when patients exercised with O2. This increase in endurance was significantly correlated with the fall in SaO2% during the air study. The improvement in exercise time with O2 was greatest in those with the most marked lung restriction. Blood lactic acid was reduced with O2 breathing.

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