Failure of Penicillin in a Newborn With Congenital Syphilis

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Abstract
A newborn had congenital syphilis, which was characterized by wide-spread infection of meninges, liver, pancreas, peritoneum, and long bones. In spite of treatment given to the mother ten days prior to delivery, and massive doses of penicillin G potassium given to the infant for 17 days after birth, viable and virulentTreponema pallidumwere recovered from both the aqueous fluid and ground eye tissue removed at the autopsy, which was performed when the child died at age 22 days.

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