Differential expression of transcription factors in the accumbens of an animal model of ADHD

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Abstract
TRANSCRIPTION factors have been used as neuronal markers in the nucleus accumbens (ACB) of male juvenile spontaneously hypertensive rats (SHR), an animal model of attention-deficit hyperactivity disorder (ADHD), to trace putative neural substrates. In SHR, immunocytochemistry and PC-assisted image analysis showed lower expression of pan-FOS, c-FOS, ZIF/268 in the shell, and the c-FOS and ZIF/268 in the core, with an increased level of JUN-B in the core. The differential lower basal expression of transcription factors in the ACB of an animal model of ADHD implies a reduced number of modules and might represent a neural substrate of the attention deficits seen in SHR and children with ADHD at low motivational levels.