RNA: Guiding Gene Silencing
- 10 August 2001
- journal article
- special viewpoints
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 293 (5532) , 1080-1083
- https://doi.org/10.1126/science.1063051
Abstract
In diverse organisms, small RNAs derived from cleavage of double-stranded RNA can trigger epigenetic gene silencing in the cytoplasm and at the genome level. Small RNAs can guide posttranscriptional degradation of complementary messenger RNAs and, in plants, transcriptional gene silencing by methylation of homologous DNA sequences. RNA silencing is a potent means to counteract foreign sequences and could play an important role in plant and animal development.Keywords
This publication has 51 references indexed in Scilit:
- A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of thelet-7Small Temporal RNAScience, 2001
- Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental TimingCell, 2001
- Requirement of CHROMOMETHYLASE3 for Maintenance of CpXpG MethylationScience, 2001
- Mobilization of transposons by a mutation abolishing full DNA methylation in ArabidopsisNature, 2001
- HC-Pro Suppression of Transgene Silencing Eliminates the Small RNAs but Not Transgene Methylation or the Mobile SignalPlant Cell, 2001
- (TRANS)GENE SILENCING IN PLANTS: How Many Mechanisms?Annual Review of Plant Biology, 2000
- RNAiCell, 2000
- Silencing of Retrotransposons in Arabidopsis and Reactivation by the ddm1 MutationPlant Cell, 2000
- A Species of Small Antisense RNA in Posttranscriptional Gene Silencing in PlantsScience, 1999
- Recognition of unusual DNA structures by human DNA(cytosine-5)methyltransferaseJournal of Molecular Biology, 1991