Abstract
Triple‐strand β‐sheets having up‐and‐down topology are widespread in proteins and occur in two forms denoted here as S‐like and Z‐like β‐sheets. In many cases they are included in super‐secondary structures of higher order. A number of such structures is described in this paper. An important feature of these super‐secondary structures is that they have a unique handedness. Another feature is that some of them only involve S‐like β‐sheets and others only Z‐like β‐sheets.