Aggressive Squamous Cell Carcinomas in Persons Infected With the Human Immunodeficiency Virus

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Abstract
ACTINICALLY INDUCED cutaneous squamous cell carcinoma (SCC) in individuals with fair skin and long-term sun damage has been typically slow growing, easily treated, and rarely metastatic (0.3%-3.7% for low-risk cutaneous tumors).1 More aggressive behavior has been correlated with multiple factors, including anatomic site, size at presentation, growth rate, histologic features, and recurrence after treatment. Higher rates of aggressive growth and metastasis occur in immunocompromised patients, especially organ transplant recipients and patients with lymphoproliferative disorders.1-6 To our knowledge, similar increased rates of SCCs or more aggressive behavior have not been reported in human immunodeficiency virus (HIV)–infected patients.

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