SH3 — an abundant protein domain in search of a function
Open Access
- 27 July 1992
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 307 (1) , 55-61
- https://doi.org/10.1016/0014-5793(92)80901-r
Abstract
Src‐homology 3 is a small protein domain of about 60 amino acid residues. It is probably made of β‐sheets. SH3 is present in a large number of eukaryotic proteins which are involved in signal transduction, cell polarization and membrane—cytoskeleton interactions. Here we review its occurrence and discuss possible functions of this domain.Keywords
This publication has 52 references indexed in Scilit:
- Conviction by geneticsNature, 1992
- Tyrosine kinases and their interactions with signalling proteinsCurrent Opinion in Genetics & Development, 1992
- Binding of SH2 Domains of Phospholipase Cγ1, GAP, and Src to Activated Growth Factor ReceptorsScience, 1990
- Homologous activators of ras in fission and budding yeastNature, 1990
- Homology of a yeast actin-binding protein to signal transduction proteins and myosin-INature, 1990
- Similarity in membrane proteinsNature, 1989
- Signal Transduction by the Platelet-Derived Growth Factor ReceptorScience, 1989
- Transforming and membrane proteinsNature, 1988
- A novel viral oncogene with structural similarity to phospholipase CNature, 1988
- The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathwayCell, 1987