The prevention of alloxan-induced diabetes in mice by the iron-chelator detapac: Suggestion of a role for iron in the cytotoxic process
- 1 March 1982
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 38 (3) , 378-379
- https://doi.org/10.1007/bf01949404
Abstract
DETAPAC, an iron-chelating agent, given to male Swiss-Webster mice prior to alloxan, was able to protect the mice from the diabetogenic actions of alloxan. In contrast EDTA, another chelating agent, offered no protection. Possible mechanisms for these effects, including inhibition of hydroxyl radical formation, will be discussed.This publication has 19 references indexed in Scilit:
- The prevention of alloxan-induced diabetes by amygdalinLife Sciences, 1980
- Influence of trace metals on alloxan cytotoxicity in pancreatic isletsFEBS Letters, 1979
- Superoxide‐dependent formation of hydroxyl radicals in the presence of iron saltsFEBS Letters, 1978
- THE REACTION BETWEEN SUPEROXIDE ANION AND HYDROGEN PEROXIDEPhotochemistry and Photobiology, 1978
- THE EFFECT OF IRON ON THE DISTRIBUTION OF SUPEROXIDE AND HYDROXYL RADICALS AS SEEN BY SPIN TRAPPING AND ON THE SUPEROXIDE DISMUTASE ASSAYPhotochemistry and Photobiology, 1978
- Superoxide‐dependent formation of hydroxyl radicals in the presence of iron chelatesFEBS Letters, 1978
- Superoxide‐dependent production of hydroxyl radical catalyzed by iron—EDTA complexFEBS Letters, 1978
- An attempt to demonstrate a reaction between superoxide and hydrogen peroxideFEBS Letters, 1976
- Stopped flow spectrophotometric observation of superoxide dismutation in aqueous solutionFEBS Letters, 1976
- The catalytic decomposition of hydrogen peroxide by iron saltsProceedings of the Royal Society of London. Series A. Mathematical and Physical Sciences, 1934