Effects of Exogenous βh-Endorphin on Pituitary Hormone Secretionand Its Disappearance Rate in Normal Human Subjects*
- 1 June 1981
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 52 (6) , 1179-1184
- https://doi.org/10.1210/jcem-52-6-1179
Abstract
The disappearance rate of the immunoreactive βh-endorphin and the effects of βh-endorphin on pituitary hormone secretion were investigated in normal volunteers. Synthetic human βh-endorphin was administered as a 2.5-mg iv bolusto five normal women resulting in a 1000-fold increase in concentration of circulating immunoreactive βh-endorphin within 2.5 min. This was followed by a triple exponential disappearance curve yielding an initial fast component with a halftime (t½ ± SD)of 4.1 (± 0.6) min, a midrange component with a t½ of 13.1 (± 0.6) min,and a slow component with (t½ of 46.2 (± 7.0) min. In both male and female subjects this dose of β-endorphin induced a significant increase in the levels of PRL and a significant decline in the concentration of LH, without altering basal levels of GH and TSH.Keywords
This publication has 3 references indexed in Scilit:
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- A Specific Homologous Radioimmunoassay for Human β-Endorphin: Direct Measurement in Biological Fluids*Journal of Clinical Endocrinology & Metabolism, 1980