Continuous-flow synthesis of vitamin D3
- 1 January 2009
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- Vol. 46 (46) , 8722-8724
- https://doi.org/10.1039/c0cc02239j
Abstract
A highly efficient, two-stage, continuous-flow synthesis of vitamin D3 from provitamin D3 was achieved. The developed method afforded the desired product in high yield (HPLC-UV: 60%, isolated: 32%) and required neither intermediate purification nor high-dilution conditions.Keywords
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