Prevention by Splenectomy of Thymus Weight Depletion in the Presence of Progressively Growing Tumor in Rats: Brief Communication 2

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Abstract
Groups of inbred rats were inoculated with the Walker 256 carcinosarcoma. The weights of their spleens and thymuses were determined on days 16 and 23 after the tumor inoculation. Spleen weights Increased progressively as the tumors grew (PPPPP<0.001). Microscopic examination of thymuses on day 23 revealed some depletion of cortical lymphocytes in splenectomized, tumor-bearing animals and profound depletion of these lymphocytes in intact, tumor-bearing animals. Tumor weights and measurements did not differ between splenectomized, tumor-bearing and intact, tumor-bearing animals. Equal rates of tumor growth provided for a roughly equal tumor burden at termination of the experiment.

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